Monday, November 19, 2012

Omega-3 Supplements for Heart Disease

"Omega-3 fatty acids, commonly sold as fish oil, have been in the news a lot lately. We know that many people in this country take omega-3 supplements. In fact, according to the 2007 National Health Interview Survey, omega-3 supplements are the most common natural product taken by U.S. adults, and the second most common supplement taken by children.

Omega-3s are important for a number of functions in the body and are studied for a variety of conditions—from rheumatoid arthritis to bipolar disorder to infant brain development to dementia. But they may be best known for their purported heart protective effects. Chances are your doctor may have even recommended that you take an omega-3 supplement to help protect against heart disease.

Based on what the science tells us, most experts agree that a diet that includes fish rich in omega-3 fatty acids is healthy, but there just isn’t good evidence that omega-3s taken as supplements protect against heart disease. And although omega-3 supplements are generally safe for most people, there may be potential safety issues in some populations
."    - Josephine P. Briggs, M.D.

According to the 2007 National Health Interview Survey, which included a comprehensive survey on the use of complementary health practices by Americans, fish oil/omega-3/DHA supplements are the natural product (excluding vitamins and minerals) most commonly taken by adults, and the second most commonly taken by children.

A pile of gelatin capsules containing fish oil high in omega-3 Author: Oddman47 Licensing: I, Oddman47, the copyright holder of this work, hereby publish it under the following license: This file is made available under the Creative Commons CC0 1.0 Universal Public Domain Dedication
There has been a substantial amount of research on omega-3 supplements and heart disease. Experts agree that fish rich in omega-3 fatty acids should be included in a heart-healthy diet. However, omega-3s in supplement form have not been shown to protect against heart disease.

Experts agree that fish rich in omega-3 fatty acids should be included in a heart-healthy diet. However, omega-3s in supplement form have not been shown to protect against heart disease.

A Diet Rich in Fish

Epidemiological studies done more than 30 years ago noted relatively low death rates due to cardiovascular disease in Eskimo populations with high fish consumption.  Since then, much research has been done on fish and heart disease. The results provide strong, though not conclusive evidence that people who eat fish at least once a week are less likely to die of heart disease than those who rarely or never eat fish.

The 2010 edition of the Federal Government’s Dietary Guidelines for Americans includes a new recommendation that adults eat 8 or more ounces of seafood (fish or shellfish) per week because it provides a range of nutrients, including omega-3 fatty acids. (Smaller amounts are recommended for young children.) The Dietary Guidelines report notes that eating the recommended amount of seafood is associated with reduced heart disease deaths.

Omega-3 Supplements and Risk of Heart Disease

Many studies have evaluated the effects of omega-3 supplements on heart disease risk. In these studies, researchers compared the number of cardiovascular events (such as heart attacks or strokes), or the number of deaths in people who were given omega-3 supplements with those in people who were given inactive substances (placebos) or standard care.
  • Most of these studies involved people who already had evidence of heart disease. A smaller number of studies included people with no history of heart disease.
  • The results of individual studies were inconsistent; some indicated that omega-3s were protective, but others did not.
  • In 2012, two groups of scientists conducted meta-analyses of these studies; one group analyzed only studies in people with a history of heart disease, and the other group analyzed studies in people both with and without a history of heart disease. Neither meta-analysis found convincing evidence of a protective effect of omega-3s.

Reasons Why Omega-3 Supplements May Not Be As Beneficial as Eating Fish

There are several reasons why omega-3 supplements may not help to prevent heart disease even though a diet rich in fish apparently does:
  • Eating fish a few times a week might provide enough omega-3s to protect the heart; more may not be better. A recent meta-analysis showed that either a low (1 serving/week) or moderate fish consumption (2 to 4 servings/week) was associated with a significant reduction in risk of heart disease mortality. However, consuming more than 5 servings of fish per week was associated with only a marginally protective effect on heart disease mortality.
  • Some of the benefits of a diet that includes regular fish consumption may be related to factors other than its omega-3 content, or result from people eating fish in place of less healthful foods.
  • There is also evidence that people who eat fish have generally healthier lifestyles, and these other lifestyle characteristics may be responsible for the lower incidence of cardiovascular disease.

  • Omega-3 fatty acid supplements usually do not have negative side effects. When side effects do occur, they typically consist of minor gastrointestinal symptoms, such as belching, indigestion, or diarrhea.
  • It is uncertain whether people with fish or shellfish allergies can safely consume fish oil supplements.
  • Omega-3 supplements may extend bleeding time (the time it takes for a cut to stop bleeding). People who take drugs that affect bleeding time, such as anticoagulants (blood thinners) or non-steroidal anti-inflammatory drugs (NSAIDs), should discuss the use of omega-3 fatty acid supplements with a health care provider.
  • Fish liver oils, such as cod liver oil, are not the same as fish oil. Fish liver oils contain vitamins A and D as well as omega-3 fatty acids. Both of these vitamins can be toxic in large doses.  The amounts of vitamins in fish liver oil supplements vary from one product to another.
  • There is conflicting evidence on how DHA might affect the risk of prostate cancer: A 2011 study found that men with higher blood levels of DHA (which reflect higher intakes of this fatty acid) had an increased risk of high-grade (more aggressive) prostate cancer,  and an earlier study found increased risks of both low-grade and high-grade prostate cancer in men with higher blood levels of DHA. However, other studies found no relationship or the opposite relationship between blood levels of DHA and prostate cancer risk, and a combined analysis of data from multiple studies showed that eating fish, which is a good source of DHA, is associated with a lower likelihood of dying from prostate cancer.

To Sum Up:
  • While the evidence is quite strong and most experts agree that fish rich in omega-3 fatty acids should be included regularly in a heart-healthy diet, there isn’t conclusive evidence that shows omega-3s have a protective effect against heart disease.
  • Omega-3 supplements should not be used to replace conventional care or as a reason to postpone seeing a health care provider about a medical problem.
  • Although omega-3 supplements are generally safe, there are some concerns about use by women who are pregnant or nursing a child, or by patients who are taking medicines that affects blood clotting, or are allergic to fish or shellfish. Also, it is especially important that parents considering giving a child an omega-3 supplement consult their child’s pediatrician or health care provider.

External Links

DHA from fish oil improves aggression and impulsivity -
Omega-3 Fatty Acids and Health - Office of Dietary Supplements (ODS).
Fish Oil - U.S. National Library of Medicine, National Institutes of Health.
Heart and Vascular Diseases - National heart Lung Blood Institute (NHLBI).
Clinical Use of Dietary Supplements and Nutraceuticals - AACE Nutrition Guidelines Task Force.
Systematic Reviews/Reviews/Meta-analysis - PubMed.
Randomized Controlled Trials - PubMed. 

Clinical Trials
Clinical Trials: Omega-3 fatty acids and heart disease -  U.S. National Institutes of Health. 

Specific Dietary Patterns May Help Prevent Cognitive Decline in Older People (01/24/12).
Omega-3 Fatty Acids May Reduce Inflammation and Anxiety in Healthy Young Adults (07/19/11).
Echium Oil Reduces Triglyceride Levels in Mice (10/01/08).
Omega-3 fatty acids may be helpful in psychiatric care (12/01/06).
Polyunsaturated Fatty Acids for Depression (05/01/06).
Time to Talk Tips: 5 things to know about Omega-3s for heart disease

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